Article
Differential virus-specific CD8+ T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4.
Journal of viral hepatitis - 1 Jul 2018
Luxenburger Hendrik, Graß Franziska, Baermann Janina, Boettler Tobias, Marget Matthias, Emmerich Florian, Panning Marcus, Thimme Robert, Nitschke Katja, Neumann-Haefelin Christoph
Abstract excerpt
Virus-specific CD8+ T-cell responses play an important role in the outcome of hepatitis C virus (HCV) infection. To date, most HCV-specific CD8+ T-cell epitopes have been defined in HCV genotype 1 infection. In contrast, the HCV genotype 4-specific CD8+ T-cell response is poorly defined. Here, we analysed whether known HCV-specific CD8+ T-cell epitopes are also recognized in HCV genotype 4-infected patients and...
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