Article
Antigenic variation of core, NS3, and NS5 proteins among genotypes of hepatitis C virus.
Journal of clinical microbiology - 1 Dec 1997
Neville J A, Prescott L E, Bhattacherjee V, Adams N, Pike I, Rodgers B, El-Zayadi A, Hamid S, Dusheiko G M, Saeed A A, Haydon G H, Simmonds P
Abstract excerpt
Assays that detect antibody to hepatitis C virus (HCV) are used to screen blood donors and patients with hepatitis. Current enzyme-linked immunosorbent assay (ELISA)-based methods are invariably based upon antigens from expressed recombinant proteins or oligopeptides from HCV type 1. Some HCV antigens used in screening assays are coded by regions of the HCV genome that show extensive variability; therefore, HCV...
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