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Article

Mutations in the cysteine-rich region of the RET proto-oncogene in patients diagnosed as having sporadic medullary thyroid carcinoma.

Endocrine journal - 1 Aug 1995

Kimura T, Yoshimoto K, Yokogoshi Y, Saito S

Abstract excerpt

Medullary thyroid carcinoma (MTC) and pheochromocytoma appear in either a sporadic or a hereditary form as components of multiple endocrine neoplasia (MEN). Many germline mutations of the RET proto-oncogene have been reported in patients with MEN 2A and 2B, and familial MTC (FMTC). To elucidate the etiological roles in tumorigenesis of sporadic MTCs and pheochromocytomas, mutations in the cysteine-rich region of...

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Identifiers

PMID: 8556059
DOI: 10.1507/endocrj.42.517

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Mutations in the cysteine-rich region of the RET proto-oncogene in patients diagnosed as having sporadic medullary thyroid carcinoma.PMID 8556059Read ↗

Germline and somatic mutations of the RET proto-oncogene in apparently sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.Semantic proximity Read ↗

RET protooncogene mutations in patients with apparently sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.Semantic proximity Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.Semantic proximity Read ↗

Somatic mutations in the RET protooncogene in Japanese and Chinese sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

RET proto-oncogene mutations in French MEN 2A and FMTC families.Semantic proximity Read ↗

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s.Semantic proximity Read ↗

RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center.Semantic proximity Read ↗

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