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Article

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.

Human molecular genetics - 1 Feb 1994

Eng C, Smith D P, Mulligan L M, Nagai M A, Healey C S, Ponder M A, Gardner E, Scheumann G F, Jackson C E, Tunnacliffe A

Abstract excerpt

The susceptibility loci for the three multiple endocrine neoplasia (MEN) type 2 syndromes have been mapped to the region of chromosome 10q11.2 containing the RET proto-oncogene, which codes for a receptor tyrosine kinase. The majority of MEN 2A and familial medullary thyroid carcinoma results from missense mutations within one of five cysteine codons in the extracellular domain of the RET proto-oncogene. We now...

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Identifiers

PMID: 7911697
DOI: 10.1093/hmg/3.2.237

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.PMID 7911697Read ↗

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.Semantic proximity Read ↗

Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.Semantic proximity Read ↗

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2.Semantic proximity Read ↗

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTCSemantic proximity Read ↗

RET proto-oncogene mutations in French MEN 2A and FMTC families.Semantic proximity Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s.Semantic proximity Read ↗

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

A single missense mutation in codon 918 of the RET proto-oncogene in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.Semantic proximity Read ↗

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