Article
Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.
Human molecular genetics - 1 Feb 1994
Eng C, Smith D P, Mulligan L M, Nagai M A, Healey C S, Ponder M A, Gardner E, Scheumann G F, Jackson C E, Tunnacliffe A
Abstract excerpt
The susceptibility loci for the three multiple endocrine neoplasia (MEN) type 2 syndromes have been mapped to the region of chromosome 10q11.2 containing the RET proto-oncogene, which codes for a receptor tyrosine kinase. The majority of MEN 2A and familial medullary thyroid carcinoma results fro...
Topics
- Adenoma
- Adrenal Gland Neoplasms
- Alleles
- Base Sequence
- Carcinoma, Medullary
- Codon
- DNA Mutational Analysis
- DNA, Neoplasm
- Drosophila Proteins
- Exons
- Hirschsprung Disease
- Hyperplasia
- Molecular Sequence Data
- Multiple Endocrine Neoplasia