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Article

RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center.

The Journal of clinical endocrinology and metabolism - 1 Dec 2007

Elisei Rossella, Romei Cristina, Cosci Barbara, Agate Laura, Bottici Valeria, Molinaro Eleonora, Sculli Mariangela, Miccoli Paolo, Basolo Fulvio, Grasso Lucia, Pacini Furio, Pinchera Aldo

Abstract excerpt

BACKGROUND: Germline RET gene mutations are causative of multiple endocrine neoplasia (MEN) 2 and may be identified by genetic screening. Three different syndromes are distinguished: MEN 2A, when medullary thyroid carcinoma (MTC) is associated with pheochromocytoma and/or parathyroid adenomas; MEN 2B, when accompanied by a marfanoid habitus and/or pheochromocytoma; and familial medullary thyroid carcinoma (FMTC),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17895320
DOI: 10.1210/jc.2007-1005

Genes

RET

Provenance

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RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center.PMID 17895320Read ↗

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