Article
Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.
Endocrine journal - 1 Apr 1995
Yoshimoto K, Tanaka C, Hamaguchi S, Kimura T, Iwahana H, Miyauchi A, Itakura M
Abstract excerpt
Sporadic pheochromocytomas, sporadic medullary thyroid carcinomas (MTCs), pheochromocytomas and/or MTCs in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations in the tyrosine kinase domain of the RET proto-oncogene by direct sequencing of PCR-amplified products or sequencing s...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- Carcinoma, Medullary
- DNA, Neoplasm
- Drosophila Proteins
- Female
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Multiple Endocrine Neoplasia Type 2a
- Mutation
- Pheochromocytoma
- Polymerase Chain Reaction
- Protein-Tyrosine Kinases
- Proto-Oncogene Mas