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Article

Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.

Endocrine journal - 1 Apr 1995

Yoshimoto K, Tanaka C, Hamaguchi S, Kimura T, Iwahana H, Miyauchi A, Itakura M

Abstract excerpt

Sporadic pheochromocytomas, sporadic medullary thyroid carcinomas (MTCs), pheochromocytomas and/or MTCs in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations in the tyrosine kinase domain of the RET proto-oncogene by direct sequencing of PCR-amplified products or sequencing subcloned DNAs from PCR-products. All tumors of 4 MEN 2B patients were confirmed to contain a heterozygous missense...

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Identifiers

PMID: 7627271
DOI: 10.1507/endocrj.42.265

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.PMID 7627271Read ↗

Mutations in the RET protooncogene in sporadic pheochromocytomas.Semantic proximity Read ↗

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.Semantic proximity Read ↗

Mutations in the cysteine-rich region of the RET proto-oncogene in patients diagnosed as having sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

A single missense mutation in codon 918 of the RET proto-oncogene in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Somatic mutations in the RET protooncogene in Japanese and Chinese sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Frequent RET protooncogene mutations in multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

RET protooncogene mutations in patients with apparently sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Analysis of inherited genetic variants in ret proto-oncogene of Brazilian patients with apparently sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s.Semantic proximity Read ↗

Absence of mutations at codon 768 of the RET proto-oncogene in sporadic and hereditary pheochromocytomas.Semantic proximity Read ↗

Germline and somatic mutations of the RET proto-oncogene in apparently sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

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