Article
Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid.
Mechanisms of development - 1 Sept 1995
Luo J, Pasceri P, Conlon R A, Rossant J, Giguère V
Abstract excerpt
Retinoic acids (RA) are vitamin A derivatives essential for normal embryonic development and viability of vertebrates. The RA signal is mediated by two distinct classes of receptors, RA receptors (RARs) and retinoid X receptors (RXRs). The RAR family is composed of three genes: RAR alpha, beta, a...
Topics
- Abnormalities, Drug-Induced
- Animals
- Base Sequence
- Embryonic and Fetal Development
- Extremities
- Female
- Ganglia
- Gene Targeting
- Genes, Homeobox
- Homozygote
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Receptors, Retinoic Acid
- Skull