A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.

doi:10.1073/pnas.0813143106

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Article

A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2009

Mascrez Bénédicte, Ghyselinck Norbert B, Chambon Pierre, Mark Manuel

Abstract excerpt

Retinoic acid (RA) receptors (RARs) alpha, beta, and gamma heterodimerized with rexinoid receptors (RXRs) alpha, beta, and gamma mediate the RA signal. To analyze the contribution of the transcriptional activity of RXRalpha, the main RXR during embryogenesis, we have engineered a mouse line harboring a transcriptionally silent RXRalpha mutant that lacks the activation functions AF1 and AF2. All homozygous mutants...

Topics

Animals
Embryo, Mammalian
Eye
Female
Genotype
Heart
Mice
Mice, Mutant Strains
Morphogenesis
Placenta
Pregnancy
Receptors, Retinoic Acid
Retinoic Acid Receptor alpha
Transcription, Genetic
Trophoblasts

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Identifiers

PMID: 19255444
DOI: 10.1073/pnas.0813143106
PMCID: PMC2657455

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