Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.

doi:10.1016/0925-4773(95)00488-2

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Article

Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.

Mechanisms of development - 1 Mar 1996

Luo J, Sucov H M, Bader J A, Evans R M, Giguère V

Abstract excerpt

Mice with targeted disruptions in retinoic acid receptor genes have been generated to assess the role of nuclear receptors as transducers of the retinoid signal during vertebrate development. Mice with mutations that disrupt all isoforms of the RAR alpha, RAR beta and RAR gamma genes as well as f...

Topics

Animals
Bone and Bones
Esophagus
Genes, Lethal
Genitalia
Heart Defects, Congenital
Mice
Mutation
Phenotype
Receptors, Retinoic Acid
Retinoic Acid Receptor alpha
Signal Transduction
Trachea
Urinary Tract

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