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Article

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.

Nature genetics - 1 May 2002

Niederreither Karen, Abu-Abed Suzan, Schuhbaur Brigitte, Petkovich Martin, Chambon Pierre, Dollé Pascal

Abstract excerpt

Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that acts in developing and adult tissues. The Cyp26a1 (cytochrome p450, 26) protein metabolizes retinoic acid into more polar hydroxylated and oxidized derivatives. Whether some of these derivatives are biologically active metabolites has been debated. Cyp26a1(-/-) mouse fetuses have lethal morphogenetic phenotypes...

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Identifiers

PMID: 11953746
DOI: 10.1038/ng876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.PMID 11953746Read ↗

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