Article
Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.
Mechanisms of development - 1 Aug 1997
Subbarayan V, Kastner P, Mark M, Dierich A, Gorry P, Chambon P
Abstract excerpt
The RAR gamma gene generates two major isoforms, RAR gamma 1 and RAR gamma 2, which originate from two distinct promoters. We report here the engineering of mice lacking RAR gamma 1, but in which RAR gamma 2 is normally expressed. The effect of this null mutation has been compared with those prev...
Topics
- Animals
- Crosses, Genetic
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Heterozygote
- Homozygote
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Phenotype
- Receptors, Retinoic Acid
- Retinoic Acid Receptor gamma