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Article

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1993

Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub M P, LeMeur M, Chambon P

Abstract excerpt

Retinoic acid (RA) plays a critical role in normal development, growth, and maintenance of certain tissues. The action of RA is thought to be mediated in part by the three nuclear receptors (RAR alpha, -beta, and -gamma), each of which is expressed as multiple isoforms. To investigate the function of the RAR alpha gene, we have disrupted, in the mouse, the whole gene or the isoform RAR alpha 1. Although RAR alpha...

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Identifiers

PMID: 8394014
DOI: 10.1073/pnas.90.15.7225
PMCID: PMC47109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.PMID 8394014Read ↗

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