Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1993

Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub M P, LeMeur M, Chambon P

Abstract excerpt

Retinoic acid (RA) plays a critical role in normal development, growth, and maintenance of certain tissues. The action of RA is thought to be mediated in part by the three nuclear receptors (RAR alpha, -beta, and -gamma), each of which is expressed as multiple isoforms. To investigate the functio...

Topics

Alleles
Animals
Carrier Proteins
Gene Expression
Genes, Lethal
Male
Mice
Mutagenesis, Insertional
RNA, Messenger
Receptors, Retinoic Acid
Restriction Mapping
Testis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 8394014
DOI: 10.1073/pnas.90.15.7225
PMCID: PMC47109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8394014-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.PMID 8394014Read ↗

Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.Semantic proximity Read ↗

Role of the retinoic acid receptor beta (RARbeta) during mouse developmentSemantic proximity Read ↗

Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid.Semantic proximity Read ↗

Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.Semantic proximity Read ↗

Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.Semantic proximity Read ↗

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.Semantic proximity Read ↗

[Genetic control of the development by retinoic acid].Semantic proximity Read ↗

Downregulation of RAR alpha in mice by antisense transgene leads to a compensatory increase in RAR beta and RAR gamma and development of lymphoma.Semantic proximity Read ↗

Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutantsSemantic proximity Read ↗

Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.Semantic proximity Read ↗

The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse developmentSemantic proximity Read ↗

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.