Article
Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2002
Huang Danyang, Chen Siming W, Gudas Lorraine J
Abstract excerpt
Expression of vertebrate Hox genes is regulated by retinoids such as retinoic acid (RA) in cell culture and in early embryonic development. Retinoic acid response elements (RAREs) have been identified in Hox gene regulatory regions, suggesting that endogenous retinoids may be involved in the direct control of Hox gene patterning functions. Previously, two RAREs located 3' of the murine Hoxb1 gene, a DR(2) RARE...
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