Article
Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.
Developmental biology - 1 Nov 1994
Mendelsohn C, Mark M, Dollé P, Dierich A, Gaub M P, Krust A, Lampron C, Chambon P
Abstract excerpt
Vertebrates are highly sensitive to both retinoic acid (RA) deficiency and excess. The RA signal is thought to be transduced by nuclear receptors (the RAR and RXR families) which activate the expression of target genes via cis-acting transcriptional enhancer elements. Each of the three RAR genes, RAR alpha, RAR beta, and RAR gamma, gives rise to several isoforms by differential usage of two promoters and...
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