Article
Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.
Developmental biology - 1 Nov 1994
Mendelsohn C, Mark M, Dollé P, Dierich A, Gaub M P, Krust A, Lampron C, Chambon P
Abstract excerpt
Vertebrates are highly sensitive to both retinoic acid (RA) deficiency and excess. The RA signal is thought to be transduced by nuclear receptors (the RAR and RXR families) which activate the expression of target genes via cis-acting transcriptional enhancer elements. Each of the three RAR genes,...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Crosses, Genetic
- DNA
- Embryo, Mammalian
- Embryo, Nonmammalian
- Embryonic and Fetal Development
- Exons
- Female
- Heterozygote
- Male
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Phenotype
