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Article

Retinoid X receptors are essential for early mouse development and placentogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999

Wendling O, Chambon P, Mark M

Abstract excerpt

Embryos carrying null mutations of both retinoid X receptors alpha and beta (RXRalpha-/-/RXRbeta-/- mutants) were generated. These mutant embryos die between 9.5 and 10.5 days of gestation and display a wide range of abnormalities. The cause of the lethality appears to be the lack of formation of the labyrinthine zone of the chorioallantoic placenta. In a thorough analysis of mutant conceptuses, we establish that...

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Identifiers

PMID: 9892670
DOI: 10.1073/pnas.96.2.547
PMCID: PMC15173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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