Article
Retinoid X receptors are essential for early mouse development and placentogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Wendling O, Chambon P, Mark M
Abstract excerpt
Embryos carrying null mutations of both retinoid X receptors alpha and beta (RXRalpha-/-/RXRbeta-/- mutants) were generated. These mutant embryos die between 9.5 and 10.5 days of gestation and display a wide range of abnormalities. The cause of the lethality appears to be the lack of formation of...
Topics
- Animals
- Dimerization
- Embryonic and Fetal Development
- Histocytochemistry
- In Situ Hybridization
- Mice
- Mice, Knockout
- Mutation
- Oligonucleotides, Antisense
- Placentation
- Receptors, Cytoplasmic and Nuclear
- Receptors, Retinoic Acid
- Retinoid X Receptors
- Transcription Factors