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Article

Mutagenesis of important amino acid reveals unconventional homologous internalization of beta(1)-adrenergic receptor.

Life sciences - 12 Aug 2009

Hossain Murad, Rashid Mamunur, Bhuiyan Mohiuddin Ahmed, Nakamura Takashi, Ozaki Masanobu, Nagatomo Takafumi

Abstract excerpt

AIMS: The study was designed to examine the internalization of Asp104Lys mutant of beta(1)-adrenergic receptor (beta(1)-AR) and compared to other mutant (Asp104Ala) and wild type receptors. Moreover, this study needs to perform the role of GRK2 (betaARK1) and beta-arrestin1 on this internalization of Asp104Lys mutant of beta(1)-AR. MAIN METHODS: Binding affinity, functional potency of agonist and agonist-induced...

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Source

Identifiers

PMID: 19580817
DOI: 10.1016/j.lfs.2009.06.015

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutagenesis of important amino acid reveals unconventional homologous internalization of beta(1)-adrenergic receptor.PMID 19580817Read ↗

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