Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2005

Pi Min, Oakley Robert H, Gesty-Palmer Diane, Cruickshank Rachael D, Spurney Robert F, Luttrell Louis M, Quarles L Darryl

Abstract excerpt

Extracellular calcium rapidly controls PTH secretion through binding to the G protein-coupled calcium-sensing receptor (CASR) expressed in parathyroid glands. Very little is known about the regulatory proteins involved in desensitization of CASR. G protein receptor kinases (GRK) and beta-arrestin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrestins
Share to beta-Arrestins
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Mice, Mutant Strains

Share to Parathyroid Glands

Share to Protein Transport

Share to Receptors, Calcium-Sensing

Source

Identifiers

PMID: 15637145
DOI: 10.1210/me.2004-0450

Genes

CASR
PTH
GRK2
GRK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15637145-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.PMID 15637145Read ↗

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.Semantic proximity Read ↗

Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.Semantic proximity Read ↗

Agonist- and protein kinase C-induced phosphorylation have similar functional consequences for gastrin-releasing peptide receptor signaling via Gq.Semantic proximity Read ↗

Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.Semantic proximity Read ↗

Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptorsSemantic proximity Read ↗

Loss of phosphorylation sites required for β-arrestin recruitment in the calcium-sensing receptor cytoplasmic region may contribute to hypocalcemiaSemantic proximity Read ↗

β-Arrestins 1 and 2 are critical regulators of inflammationSemantic proximity Read ↗

Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function.Semantic proximity Read ↗

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.Semantic proximity Read ↗

Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.Semantic proximity Read ↗

Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTH-related protein receptors and regulation of cyclic adenosine 3',5'-monophosphate signaling by beta-arrestin2.Semantic proximity Read ↗

Receptor/beta-arrestin complex formation and the differential trafficking and resensitization of beta2-adrenergic and angiotensin II type 1A receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.