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Article

Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.

The Journal of biological chemistry - 25 Jul 2008

Nelson Christopher D, Kovacs Jeffery J, Nobles Kelly N, Whalen Erin J, Lefkowitz Robert J

Abstract excerpt

Members of the seven-transmembrane receptor (7TMR) superfamily are sequestered from the plasma membrane following stimulation both to limit cellular responses as well as to initiate novel G protein-independent signaling pathways. The best studied mechanism for 7TMR internalization is via clathrin-coated pits, where clathrin and adaptor protein complex 2 nucleate and polymerize upon encountering the membrane...

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Source

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Identifiers

PMID: 18534983
DOI: 10.1074/jbc.M800431200
PMCID: PMC2475702

Genes

PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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