Mutations of the p53 gene in myelodysplastic syndrome and overt leukemia.

doi:10.1016/0145-2126(95)00058-5

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Article

Mutations of the p53 gene in myelodysplastic syndrome and overt leukemia.

Leukemia research - 1 Nov 1995

Mori N, Hidai H, Yokota J, Okada M, Motoji T, Oshimi K, Mizoguchi H

Abstract excerpt

We analysed p53 mutations in 24 patients with myelodysplastic syndrome (MDS) and overt acute myeloid leukaemia after a period of MDS, using polymerase chain reaction-single strand conformation polymorphism analysis. In exons 5 to 8, mobility shifts were detected in five of the 24 patients. Sequen...

Topics

Base Sequence
DNA Mutational Analysis
Genes, p53
Humans
Leukemia, Myeloid, Acute
Molecular Sequence Data
Mutation
Myelodysplastic Syndromes
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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