Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the p53 gene in myelodysplastic syndrome and overt leukemia.

Leukemia research - 1 Nov 1995

Mori N, Hidai H, Yokota J, Okada M, Motoji T, Oshimi K, Mizoguchi H

Abstract excerpt

We analysed p53 mutations in 24 patients with myelodysplastic syndrome (MDS) and overt acute myeloid leukaemia after a period of MDS, using polymerase chain reaction-single strand conformation polymorphism analysis. In exons 5 to 8, mobility shifts were detected in five of the 24 patients. Sequence analysis was subsequently performed, and four missense mutations (16.7%) and one silent nucleotide substitution were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Mutational Analysis
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Point Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 8551805
DOI: 10.1016/0145-2126(95)00058-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the p53 gene in myelodysplastic syndrome and overt leukemia.PMID 8551805Read ↗

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.Semantic proximity Read ↗

P53 mutation in advanced stage of primary myelodysplastic syndrome.Semantic proximity Read ↗

TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities.Semantic proximity Read ↗

Mutations in the p53 gene in myelodysplastic syndromes.Semantic proximity Read ↗

Mutations of the p53 tumour suppressor gene in haematologic neoplasms.Semantic proximity Read ↗

Detection of p53 mutations using nonradioactive SSCP analysis: p53 is not frequently mutated in myelodysplastic syndromes (MDS).Semantic proximity Read ↗

Detection of serum anti p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia.Semantic proximity Read ↗

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.Semantic proximity Read ↗

Mutations With Loss of Heterozygosity of p53 Are Common in Therapy-Related Myelodysplasia and Acute Myeloid Leukemia After Exposure to Alkylating Agents and Significantly Associated With Deletion or Loss of 5q, a Complex Karyotype, and a Poor PrognosisSemantic proximity Read ↗

[Molecular study on minute alterations of the p53 and the N-ras genes in hematologic malignancies].Semantic proximity Read ↗

Mutations of the P53 gene in acute myeloid leukaemia.Semantic proximity Read ↗

Frequent mutations in the p53 gene in human myeloid leukemia cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.