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Article

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.

Leukemia - 1 Nov 1993

Preudhomme C, Lepelley P, Vachee A, Soenen V, Quesnel B, Cosson A, Fenaux P

Abstract excerpt

P glycoprotein, the product of multidrug resistance (mdr1) gene, is frequently expressed in advanced myelodysplastic syndromes (MDS) with an excess of bone marrow blasts and could explain their frequent resistance to chemotherapy. P53 gene mutations are also found in 10 to 15% of advanced MDS. Because it has recently been suggested that normal p53 suppressed, but that mutated p53 activated, the mdr1 gene...

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Identifiers

PMID: 7901457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.PMID 7901457Read ↗

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Detection of serum anti p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia.Semantic proximity Read ↗

Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis.Semantic proximity Read ↗

Detection of p53 mutations using nonradioactive SSCP analysis: p53 is not frequently mutated in myelodysplastic syndromes (MDS).Semantic proximity Read ↗

Mutations of the p53 tumour suppressor gene in haematologic neoplasms.Semantic proximity Read ↗

Coexpression of p53 protein and MDR functional phenotype in leukemias: the predominant association in chronic myeloid leukemia.Semantic proximity Read ↗

Cancer chemoresistance: The relationship between p53 and multidrug transportersSemantic proximity Read ↗

P53 gene mutations in acute myelogenous leukaemia.Semantic proximity Read ↗

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression.Semantic proximity Read ↗

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