Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.

Leukemia - 1 Nov 1993

Preudhomme C, Lepelley P, Vachee A, Soenen V, Quesnel B, Cosson A, Fenaux P

Abstract excerpt

P glycoprotein, the product of multidrug resistance (mdr1) gene, is frequently expressed in advanced myelodysplastic syndromes (MDS) with an excess of bone marrow blasts and could explain their frequent resistance to chemotherapy. P53 gene mutations are also found in 10 to 15% of advanced MDS. Be...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Carrier Proteins
Drug Resistance
Gene Expression
Gene Expression Regulation
Genes, p53
Humans
Membrane Glycoproteins
Mutation
Myelodysplastic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7901457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7901457-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.PMID 7901457Read ↗

Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with a stem cell phenotype.Semantic proximity Read ↗

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.Semantic proximity Read ↗

P53 mutation in advanced stage of primary myelodysplastic syndrome.Semantic proximity Read ↗

Mutations of the p53 gene in myelodysplastic syndrome and overt leukemia.Semantic proximity Read ↗

Detection of serum anti p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia.Semantic proximity Read ↗

Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis.Semantic proximity Read ↗

Detection of p53 mutations using nonradioactive SSCP analysis: p53 is not frequently mutated in myelodysplastic syndromes (MDS).Semantic proximity Read ↗

Mutations of the p53 tumour suppressor gene in haematologic neoplasms.Semantic proximity Read ↗

Coexpression of p53 protein and MDR functional phenotype in leukemias: the predominant association in chronic myeloid leukemia.Semantic proximity Read ↗

Cancer chemoresistance: The relationship between p53 and multidrug transportersSemantic proximity Read ↗

P53 gene mutations in acute myelogenous leukaemia.Semantic proximity Read ↗

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.