Article
[Molecular study on minute alterations of the p53 and the N-ras genes in hematologic malignancies].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 May 1994
Kurosawa M
Abstract excerpt
Minute alterations of the p53 tumor suppressor gene and N-ras oncogene were investigated in 106 samples for the p53 gene and 23 samples for the N-ras gene obtained from patients with various types of hematologic malignancies using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and direct nucleotide sequencing. Mobility shifts suggesting sequence alteration were observed in 9 cases...
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