Article
Detection of serum anti p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia.
Leukemia - 1 Sept 1994
Preudhomme C, Lubin R, Lepelley P, Vanrumbeke M, Fenaux P
Abstract excerpt
In solid tumors, p53 antibodies are found in 30% of the patients with p53 mutations, and their analysis is an interesting method for the detection of p53 mutations. We looked for circulating p53 antibodies in 83 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), by an E...
Topics
- Antibodies, Neoplasm
- DNA Mutational Analysis
- DNA, Single-Stranded
- Enzyme-Linked Immunosorbent Assay
- Exons
- Genes, p53
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Myelodysplastic Syndromes
- Nucleic Acid Conformation
- Polymorphism, Genetic
- Tumor Suppressor Protein p53