Article
Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions.
International journal of cancer - 20 Dec 1995
Eiriksdottir G, Sigurdsson A, Jonasson J G, Agnarsson B A, Sigurdsson H, Gudmundsson J, Bergthorsson J T, Barkardottir R B, Egilsson V, Ingvarsson S
Abstract excerpt
Primary breast tumors were tested for loss of heterozygosity (LOH), on chromosome 9p with microsatellite markers restricted to a 28 cM region including the MTS1 gene. LOH was found with at least 1 marker in 38% of the 201 cases analyzed. A high frequency of deletions was detected at the 9p23-p21...
Topics
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 6
- Chromosomes, Human, Pair 9
- Female
- Gene Deletion
- Heterozygote
- Humans
- Microsatellite Repeats
- Prognosis