Article
Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer.
Cancer - 1 Nov 2005
Hirao Shuya, Hirao Tomoko, Marsit Carmen J, Hirao Yoko, Schned Alan, Devi-Ashok Tara, Nelson Heather H, Andrew Angeline, Karagas Margaret R, Kelsey Karl T
Abstract excerpt
BACKGROUND: Somatic loss of the 9q allele as well as alteration of the tumor suppressor p53 occurs commonly in bladder cancers. Although alteration of p53 has been strongly associated with invasive stage disease, the prognostic significance of 9q loss of heterozygosity (LOH) and the relations between these alterations are less well defined. METHODS: The 9q LOH was examined at five microsatellites and p53...
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