Negative signalling via the P58/NKR for HLA.C alleles.

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Article

Negative signalling via the P58/NKR for HLA.C alleles.

European journal of histochemistry : EJH - 1 Jan 1994

Vitale M, Sivori S, Sanseverino L, Barbaresi M, Morelli L, Olcese L, Agugliano R, Bottino C, Moretta A

Abstract excerpt

Recent studies have demonstrated that the interaction between HLA class I alleles and specific NK receptors results in negative signals which inhibit NK-mediated cytotoxicity. Such NK receptors have been identified by GL183 and EB6 mAbs which recognize distinct members of a molecular family invol...

Topics

Alleles
Animals
Antibodies, Monoclonal
Antibody Specificity
Clone Cells
Cytotoxicity Tests, Immunologic
Flow Cytometry
HLA-C Antigens
Humans
Immunoglobulin Fab Fragments
Killer Cells, Natural
Mice
Protein Sorting Signals

Source

Open in PubMed

Identifiers

PMID: 8547713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8547713-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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