Article
Negative signalling via the P58/NKR for HLA.C alleles.
European journal of histochemistry : EJH - 1 Jan 1994
Vitale M, Sivori S, Sanseverino L, Barbaresi M, Morelli L, Olcese L, Agugliano R, Bottino C, Moretta A
Abstract excerpt
Recent studies have demonstrated that the interaction between HLA class I alleles and specific NK receptors results in negative signals which inhibit NK-mediated cytotoxicity. Such NK receptors have been identified by GL183 and EB6 mAbs which recognize distinct members of a molecular family involved in the recognition of two groups of HLA.C alleles. Now we describe a new allospecific NK group (group 0) which...
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