Article
CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies.
European journal of immunology - 1 Oct 1996
Sivori S, Vitale M, Bottino C, Marcenaro E, Sanseverino L, Parolini S, Moretta L, Moretta A
Abstract excerpt
CD94 molecules have been suggested to function as inhibitory natural killer cell (NK) receptors involved in the recognition of HLA-B alleles sharing the Bw6 supertypic specificity. In this study, we show that CD94 molecules may play a more general role: they are also involved in the recognition o...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Histocompatibility Antigens Class I
- Humans
- Killer Cells, Natural
- Lectins, C-Type
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- NK Cell Lectin-Like Receptor Subfamily D
- Receptors, Immunologic