Article
Distribution and lytic activity of NK cell subsets in the elderly.
Mechanisms of ageing and development - 20 Oct 1994
Mariani E, Monaco M C, Cattini L, Sinoppi M, Facchini A
Abstract excerpt
Old subjects present an increased number of NK cells associated with a decreased lytic activity of isolated and cloned CD16 cells. Recently, two new surface molecules of 58 kDa, identified by the monoclonal antibodies GL183 and EB6, have been described. The presence of these molecules, which can be coexpressed on CD16+ cells allows the recognition of the NK cell subsets whose cytolytic activity is restricted to...
Topics
- Aged
- Aged, 80 and over
- Aging
- Antibodies, Monoclonal
- Antigens, Differentiation
- Cytotoxicity, Immunologic
- Female
- Humans
- In Vitro Techniques
- Interferon-beta
- Interleukin-2