Article
Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.
The Journal of experimental medicine - 1 Aug 1994
Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L
Abstract excerpt
GL183 or EB6 (p58) molecules have been shown to function as receptors for different HLA-C alleles and to deliver an inhibitory signal to natural killer (NK) cells, thus preventing lysis of target cells. In this study, we analyzed a subset of NK cells characterized by a p58-negative surface phenot...
Topics
- Alleles
- Antibodies, Monoclonal
- Antigens, CD
- Clone Cells
- Flow Cytometry
- HLA-B Antigens
- Histocompatibility Antigens Class I
- Humans
- Killer Cells, Natural
- NK Cell Lectin-Like Receptor Subfamily D
- Phenotype
- Receptors, Antigen
- Receptors, IgG