Article
Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack?
Blood - 15 Apr 2004
Demanet Christian, Mulder Arend, Deneys Veronique, Worsham Maria J, Maes Piet, Claas Frans H, Ferrone Soldano
Abstract excerpt
Human leukocyte antigen (HLA) class I antigen defects may have a negative impact on the growing application of T-cell-based immunotherapeutic strategies for treatment of leukemia. Therefore in the present study, taking advantage of a large panel of HLA class I allele-specific human monoclonal antibodies, we have compared HLA class I antigen expression on leukemic cells with that on autologous and allogeneic...
Topics
- Alleles
- Antibodies, Monoclonal
- Antibody Specificity
- Cell Line, Tumor
- Down-Regulation
- Flow Cytometry
- Gene Expression
- HLA-A Antigens
- HLA-B Antigens
- Humans
- Killer Cells, Natural
- Leukemia
- Mutation
- T-Lymphocytes, Cytotoxic