Article
A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1997
Winter C C, Long E O
Abstract excerpt
To examine the structural basis for the specific recognition of the MHC class I allotypes HLA-Cw*0401 and HLA-Cw*0304 by the killer cell inhibitory receptors (KIR) cl42 and cl43, respectively, mutant KIR-Ig fusion proteins were tested by direct binding to cells transfected with single HLA-C allel...
Topics
- Alleles
- Amino Acid Sequence
- Consensus Sequence
- HLA-C Antigens
- Humans
- Killer Cells, Natural
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Receptors, Immunologic
- Receptors, KIR
- Receptors, KIR2DL3
- Recombinant Fusion Proteins
- Structure-Activity Relationship