Article
Role of receptors in human and rodent hepatocarcinogenesis.
Mutation research - 1 Dec 1995
Schwarz M, Buchmann A, Stinchcombe S, Luebeck G, Moolgavkar S, Bock K W
Abstract excerpt
The liver is a major target organ in rodent carcinogenicity assays. Amongst the agents that are effective in producing rodent liver tumours are many chemicals which are not mutagenic, but are believed to mediate their effects by promoting the clonal outgrowth of initiated cells. Some of these chemicals, such as dibenzo-p-dioxins and certain PCBs, have been demonstrated to interact with specific cellular receptors...
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