Article
Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro.
Toxicology - 15 Mar 2017
Boess Franziska, Lenz Barbara, Funk Juergen, Niederhauser Urs, Bassett Simon, Zhang Jitao David, Singer Thomas, Roth Adrian B
Abstract excerpt
Foci of altered hepatocytes (FAH) are considered putative, pre-neoplastic lesions that can occur spontaneously in aging rodents, but can also be induced by chemicals or drugs. Progression of FAH to hepatocellular neoplasms has been reported repeatedly but increases in foci in rodents do not necessarily lead to tumors in carcinogenicity studies and the relevance for humans often remains unclear. Here we present...
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