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Article

Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences

1 Feb 1999

Abstract excerpt

Peroxisome proliferators (PPs) are chemicals of industrial and pharmaceutical importance that elicit liver carcinogenesis by a non-genotoxic mechanism. One of the intriguing properties of PPs is that the pleiotropic effects of these compounds (including increased DNA synthesis and peroxisome proliferation) are seen in rats and mice only, but not humans. It is important to determine the risks to humans of...

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PMID: 9924174
DOI: 10.1677/jme.0.0220001

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