Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Abstract excerpt

Many nongenotoxic chemicals have been shown to produce liver tumors in mice and/or rats by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR). Studies with phenobarbital (PB) and other compounds have identified the key events for this MOA: CAR activation; increased hepatocellular proliferation; altered foci formation; and ultimately the development of adenomas/carcinomas. In...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Eicosanoids and Hypertension Pharmacology
• Share to Inflammatory mediators and NSAID effects
• Share to Pharmacogenetics and Drug Metabolism