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Article

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

21 Jul 2009

Abstract excerpt

Phenobarbitone and related compounds induce hepatic microsomal cytochrome P450 (CYP) 2B forms (mediated by the constitutive androstane receptor), whereas peroxisome proliferators induce CYP4A forms (mediated by the peroxisome proliferator-activated receptor alpha) in rats and mice. A number of non-genotoxic CYP2B and CYP4A inducers have been shown to produce liver tumours in rats and mice. The hepatic effects of...

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PMID: 19622001
DOI: 10.1080/00498250903098184

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