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Article

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

Molecular and cellular biology - 1 Apr 1993

Whitelaw M, Pongratz I, Wilhelmsson A, Gustafsson J A, Poellinger L

Abstract excerpt

The intracellular basic region/helix-loop-helix (bHLH) dioxin receptor mediates signal transduction by dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) and functions as a ligand-activated DNA binding protein directly interacting with target genes by binding to dioxin response elements. Here we show that the partially purified, ligand-bound receptor alone could not bind target DNA. In contrast, DNA binding by the...

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Identifiers

PMID: 8384309
DOI: 10.1128/mcb.13.4.2504-2514.1993
PMCID: PMC359572

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