Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

doi:10.1128/mcb.13.4.2504-2514.1993

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Article

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

Molecular and cellular biology - 1 Apr 1993

Whitelaw M, Pongratz I, Wilhelmsson A, Gustafsson J A, Poellinger L

Abstract excerpt

The intracellular basic region/helix-loop-helix (bHLH) dioxin receptor mediates signal transduction by dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) and functions as a ligand-activated DNA binding protein directly interacting with target genes by binding to dioxin response elements. Here we show t...

Topics

Animals
Aryl Hydrocarbon Receptor Nuclear Translocator
DNA Mutational Analysis
DNA-Binding Proteins
Gene Expression Regulation
Heat-Shock Proteins
In Vitro Techniques
Ligands
Liver Neoplasms, Experimental
Macromolecular Substances
Mutation
Nuclear Proteins
Promoter Regions, Genetic
Proteins
Receptors, Aryl Hydrocarbon
Receptors, Drug
Recombinant Proteins
Sequence Deletion

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Identifiers

PMID: 8384309
DOI: 10.1128/mcb.13.4.2504-2514.1993
PMCID: PMC359572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8384309-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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