Article
Covariate effects on linkage and association using a general pair method.
Genetic epidemiology - 1 Jan 1997
Ward P J
Abstract excerpt
The "general pair method" (GPM) is a nonparametric, identity-by-state (IBS) method of assessing linkage between a chromosomal marker and a binary phenotype. It is applicable to any pedigree structure, and uses marker information from affected as well as unaffected individuals. Results obtained here from nuclear families (Problem 2A) are contrasted with those from extended pedigrees (Problem 2B). Test statistics...
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