Covariate effects on linkage and association using a general pair method.

doi:10.1002/(SICI)1098-2272(1997)14:6<1059::AID-GEPI83>3.0.CO;2-G

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Article

Covariate effects on linkage and association using a general pair method.

Genetic epidemiology - 1 Jan 1997

Ward P J

Abstract excerpt

The "general pair method" (GPM) is a nonparametric, identity-by-state (IBS) method of assessing linkage between a chromosomal marker and a binary phenotype. It is applicable to any pedigree structure, and uses marker information from affected as well as unaffected individuals. Results obtained he...

Topics

Analysis of Variance
Environment
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Humans
Male
Phenotype
Quantitative Trait, Heritable
Statistics, Nonparametric

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