Nonparametric simulation based linkage statistics for general pedigrees.

Article

Nonparametric simulation based linkage statistics for general pedigrees.

The Journal of rheumatology - 1 Jan 1997

Weeks D E, Davis S, Schroeder M, Goldin L R

Abstract excerpt

A common strategy for testing for linkage without posing a disease model is to test for increased marker similarity among the affected pedigree members. We developed a simulation based statistic, SimIBD, which measures marker similarity in terms of identity-by-descent (IBD) when it can be determi...

Topics

Alleles
Arthritis, Rheumatoid
Computer Simulation
Genetic Linkage
Humans
Pedigree
Software

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