Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci.

Article

Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci.

American journal of human genetics - 1 Dec 1995

McKenzie C A, Julier C, Forrester T, McFarlane-Anderson N, Keavney B, Lathrop G M, Ratcliffe P J, Farrall M

Abstract excerpt

Human serum angiotensin I-converting enzyme (ACE) levels vary substantially between individuals and are highly heritable. Segregation analysis in European families has shown that more than half of the total variability in ACE levels is influenced by quantitative-trait loci (QTL). One of these QTL...

Topics

Analysis of Variance
Blood Pressure
Case-Control Studies
Genetic Linkage
Genotype
Humans
Hypertension
Jamaica
Peptidyl-Dipeptidase A

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