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Linkage mapping of CVD risk traits in the isolated Norfolk Island population.

Human genetics - 1 Dec 2008

Bellis C, Cox H C, Dyer T D, Charlesworth J C, Begley K N, Quinlan S, Lea R A, Heath S C, Blangero J, Griffiths L R

Abstract excerpt

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377 individuals from the Norfolk Island population. The central aim of this research focused on the utilization of a genetically and geographically isolated population of individuals from Norfolk Island for the purposes of variance...

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PMID: 18975005
DOI: 10.1007/s00439-008-0580-y
PMCID: PMC2633922

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