Article
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study.
Circulation - 12 May 1998
O'Donnell C J, Lindpaintner K, Larson M G, Rao V S, Ordovas J M, Schaefer E J, Myers R H, Levy D
Abstract excerpt
BACKGROUND: There is controversy regarding the association of the angiotensin-converting enzyme deletion-insertion (ACE D/I) polymorphism with systemic hypertension and with blood pressure. We investigated these relations in a large population-based sample of men and women by using association and linkage analyses. METHODS AND RESULTS: The study sample consisted of 3095 participants in the Framingham Heart Study....
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