Article
High-resolution genetic mapping of the ACE-linked QTL influencing circulating ACE activity.
European journal of human genetics : EJHG - 1 Sept 2002
Soubrier Florent, Martin Sabrina, Alonso Amalia, Visvikis Sophie, Tiret Laurence, Matsuda Fumihiko, Lathrop G Mark, Farrall Martin
Abstract excerpt
Fine-mapping of trait loci through combined linkage and association analysis is an important component of strategies designed to identify causative gene variants, particularly in situations where the trait may be influenced by one or more of many polymorphisms within the same gene. Angiotensin-1 converting enzyme (ACE) provides one of the best models for developing and testing such methodologies, as a major...
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