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Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation.

Oncogene - 11 Mar 1999

Sekiguchi T, Nishimoto T, Hunter T

Abstract excerpt

tsBN462 cells, which have a point mutation in CCG1/TAF(II)250, a component of TFIID complex, arrest in G1 at the nonpermissive temperature of 39.5 degrees C. Overexpression of D-type cyclins rescued the cell cycle arrest of tsBN462 cells, suggesting that the cell cycle arrest was through Rb. Consistent with this, overexpression of E2F-1, whose function is repressed by the hypophosphorylated form of Rb, also...

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PMID: 10086334
DOI: 10.1038/sj.onc.1202508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation.PMID 10086334Read ↗

D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.Semantic proximity Read ↗

Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250.Semantic proximity Read ↗

Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression.Semantic proximity Read ↗

Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells.Semantic proximity Read ↗

Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250.Semantic proximity Read ↗

The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.Semantic proximity Read ↗

Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.Semantic proximity Read ↗

Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1.Semantic proximity Read ↗

A point mutation in C-terminal region of cdc2 kinase causes a G2-phase arrest in a mouse temperature-sensitive FM3A cell mutant.Semantic proximity Read ↗

TGF-β Induces Growth Arrest in Burkitt Lymphoma Cells via Transcriptional Repression of E2F-1Semantic proximity Read ↗

Cyclin-dependent kinase 2 (cdk2) in the murine Cdc2 kinase TS mutant.Semantic proximity Read ↗

tsJT16, a cell cycle ts mutant of rat fibroblast defective in early G0/G1 transition, fails to induce G1-cyclin and cdk2 genes after serum stimulation at the nonpermissive temperature.Semantic proximity Read ↗

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