D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.

doi:10.1046/j.1365-2443.1996.00259.x

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Article

D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 1996

Sekiguchi T, Noguchi E, Hayashida T, Nakashima T, Toyoshima H, Nishimoto T, Hunter T

Abstract excerpt

BACKGROUND: The tsBN462 temperature-sensitive mutant hamster cell line exhibits cell cycle arrest and apoptosis at the restrictive temperature of 39.5 degrees C, due to a point mutation in the CCG1/TAFII250 gene, which encodes a component of the general transcription factor TFIID. RESULTS: We now...

Topics

Animals
Cell Line
Cricetinae
Cyclin D
Cyclin-Dependent Kinases
Cyclins
DNA-Binding Proteins
G1 Phase
Gene Expression
Genes, Immediate-Early
Histone Acetyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Phosphorylation

Retinoblastoma Protein

TATA-Binding Protein Associated Factors

Temperature

Transcription Factor TFIID

Source

Open in PubMed

Identifiers

PMID: 9078394
DOI: 10.1046/j.1365-2443.1996.00259.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9078394-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.PMID 9078394Read ↗

Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation.Semantic proximity Read ↗

Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250.Semantic proximity Read ↗

The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.Semantic proximity Read ↗

Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.Semantic proximity Read ↗

Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression.Semantic proximity Read ↗

Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250.Semantic proximity Read ↗

TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins.Semantic proximity Read ↗

A point mutation in C-terminal region of cdc2 kinase causes a G2-phase arrest in a mouse temperature-sensitive FM3A cell mutant.Semantic proximity Read ↗

Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1.Semantic proximity Read ↗

tsJT16, a cell cycle ts mutant of rat fibroblast defective in early G0/G1 transition, fails to induce G1-cyclin and cdk2 genes after serum stimulation at the nonpermissive temperature.Semantic proximity Read ↗

Cyclin-dependent kinase 2 (cdk2) in the murine Cdc2 kinase TS mutant.Semantic proximity Read ↗

Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells.Semantic proximity Read ↗

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