TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

doi:10.1091/mbc.7.9.1335

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Article

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

Molecular biology of the cell - 1 Sept 1996

Herrera R E, Mäkelä T P, Weinberg R A

Abstract excerpt

Transforming growth factor beta (TGF beta) inhibits cell proliferation by inducing a G1 cell-cycle arrest. Cyclin/CDK complexes have been implicated in this arrest, because TGF beta treatment leads to inhibition of cyclin/CDK activity. We have investigated the role of the retinoblastoma protein (...

Topics

Animals
CDC2-CDC28 Kinases
Cell Cycle Proteins
Cell Division
Cells, Cultured
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases
Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo, Mammalian

Fibroblasts

Growth Substances

Mice

Mice, Mutant Strains

Microtubule-Associated Proteins

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8885230
DOI: 10.1091/mbc.7.9.1335
PMCID: PMC275985

Genes

CDK2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8885230-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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