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tsJT16, a cell-cycle ts mutant defective in a function operating soon after growth stimulation, fails to induce a primarily activated labile nuclear protein.

Cell structure and function - 1 Feb 1990

Takasuka T, Sakayama M, Ishibashi S, Ide T

Abstract excerpt

tsJT16 is a temperature-sensitive (ts) mutant of rat fibroblasts that has a ts defect in a function operating soon after the growth stimulation from the G0 phase. After the growth stimulation, the cells express several cell-cycle-dependent genes at both temperatures while they fail at the nonpermissive temperature to synthesize a protein p70 identified on two-dimensional gel electrophoresis. Here we report that...

Topics

Animals
Blood Physiological Phenomena
Cell Cycle
Cell Division
Cell Line
Dactinomycin
Electrophoresis, Gel, Two-Dimensional
Half-Life
Molecular Weight
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Subcellular Fractions

Temperature

Source

Identifiers

PMID: 2340589
DOI: 10.1247/csf.15.47

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2340589-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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tsJT16, a cell-cycle ts mutant defective in a function operating soon after growth stimulation, fails to induce a primarily activated labile nuclear protein.PMID 2340589Read ↗

A nuclear labile protein, p70, is expressed exclusively during G0-S transition but not in G1 phase of a cell cycle ts mutant, tsJT16.Semantic proximity Read ↗

A temperature-sensitive cell-cycle mutant of mammalian cells, tsJT16, is defective in a function operating soon after growth stimulation.Semantic proximity Read ↗

A cell cycle ts mutant, tsJT16, is defective in p70 synthesis through protein kinase C-dependent and -independent pathways.Semantic proximity Read ↗

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