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Article

K-ras mutations in benzotrichloride-induced lung tumors of A/J mice.

Carcinogenesis - 1 Jun 1993

You M, Wang Y, Nash B, Stoner G D

Abstract excerpt

Benzotrichloride (BTC) is used extensively as a chemical intermediate in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. BTC is also a carcinogen in the A/J mouse lung tumor bioassay. Activated K-ras protooncogenes were detected in BTC-induced lung tumors from A/J mice. The polymerase chain reaction was used to amplify specific DNA segments...

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Source

Identifiers

PMID: 8508514
DOI: 10.1093/carcin/14.6.1247

Genes

BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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