Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.

doi:10.1093/carcin/18.10.1955

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Article

Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.

Carcinogenesis - 1 Oct 1997

Prahalad A K, Ross J A, Nelson G B, Roop B C, King L C, Nesnow S, Mass M J

Abstract excerpt

Dibenzo[a,l]pyrene (DB[a,l]P), an environmental polycyclic aromatic hydrocarbon, is the most potent carcinogen ever tested in mouse skin and rat mammary gland. In this study, DB[a,l]P was examined for DNA adduction, tumorigenicity, and induction of Ki-ras oncogene mutations in tumor DNA in strain...

Topics

Adenoma
Animals
Benzopyrenes
Carcinogens
Chromatography, Thin Layer
DNA Adducts
Genes, ras
Lung
Lung Neoplasms
Male
Mice
Mice, Inbred A
Mutation

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