Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.

doi:10.1093/carcin/15.11.2613

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Article

Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.

Carcinogenesis - 1 Nov 1994

You L, Wang D, Galati A J, Ross J A, Mass M J, Nelson G B, Wilson K H, Amin S, Stoner J C, Nesnow S

Abstract excerpt

This study was undertaken to evaluate the carcinogenic potential of 5-methylchrysene (5-MeC) in strain A/J mouse lung and to correlate the 5-MeC-DNA adduct profile in lung tissue with the mutation spectrum in the K-ras gene of lung tumors. Strain A/J mice received a single i.p. injection of 5-MeC...

Topics

Animals
Carcinogens
Chrysenes
DNA
DNA Adducts
Genes, ras
Lung Neoplasms
Male
Mice
Mutation
Polymorphism, Single-Stranded Conformational

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