Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations induced by benzo[a]pyrene and dibenzo[a,l]pyrene in lacI transgenic B6C3F1 mouse lung result from stable DNA adducts.

Mutagenesis - 1 Nov 2008

Leavitt Sharon A, George Michael H, Moore Tanya, Ross Jeffrey A

Abstract excerpt

Dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P) are carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are each capable of forming a variety of covalent adducts with DNA. Some of the DNA adducts formed by these PAHs have been demonstrated to spontaneously depurinate, producing apurinic (AP) sites. The significance of the formation of AP sites as a key event in the production of mutations and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzo(a)pyrene
Share to Carcinogens
Share to DNA Adducts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to Lac Repressors

Share to Mice, Transgenic

Share to Repressor Proteins

Source

Identifiers

PMID: 18573814
DOI: 10.1093/mutage/gen033

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations induced by benzo[a]pyrene and dibenzo[a,l]pyrene in lacI transgenic B6C3F1 mouse lung result from stable DNA adducts.PMID 18573814Read ↗

Treatment of lacZ plasmid-based transgenic mice with benzo[a]pyrene: measurement of DNA adduct levels, mutant frequencies, and mutant spectra.Semantic proximity Read ↗

In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice.Semantic proximity Read ↗

Mechanistic relationships between DNA adducts, oncogene mutations, and lung tumorigenesis in strain A mice.Semantic proximity Read ↗

Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.Semantic proximity Read ↗

Differential mutation of transgenic and endogenous loci in vivo.Semantic proximity Read ↗

Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 lacI transgenic mice (Big Blue): a review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure.Semantic proximity Read ↗

Frequency and spectrum of lacI mutations in the liver of Big Blue mice following the administration of genotoxic carcinogens singly and in series.Semantic proximity Read ↗

LacZ transgenic mouse models: their application in genetic toxicology.Semantic proximity Read ↗

Comparison of the mutational spectra of the lacZ transgene in four organs of the MutaMouse treated with benzo[a]pyrene: target organ specificity.Semantic proximity Read ↗

Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing.Semantic proximity Read ↗

The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin.Semantic proximity Read ↗

Multiple organ mutation in the lacZ transgenic mouse (Muta mouse) 6 months after oral treatment (5 days) with benzo[a]pyrene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.